AAV Contract Development And Manufacturing Organizations Market Insights and Forecast By 2035

The global AAV Contract Development And Manufacturing Organizations Market size is expected to reach USD 4.7 billion by 2035 and it is expected to expand at 17.1% CAGR from 2023 to 2035, according to a new report by Grand View Research, Inc. The main drivers of this market are the robust pipeline of adeno-associated virus (AAV) for gene therapies & vaccines, technological advancements in manufacturing of adeno-associated viral vectors, and a highly competitive market with various strategies undertaken by key market players. For instance, in September 2022, Rocket Pharmaceuticals, Inc. acquired Renovacor, Inc., a biotechnology company, focused on offering precision medicines. This acquisition is in line with the company's aim to strengthen its position as a pioneer in adeno-associated virus (AAV)-based gene therapy for cardiac illness.

AAV-mediated gene therapy products that address fatal and severely disabling diseases have proliferated in recent years, with investment in academic startups, and several products entering clinical trials by major pharmaceutical companies. AAV vector has become a highly effective treatment for cardiovascular, neurological, and immunological illnesses as well as cancer. Due to these factors, market participants and CDMOs implement strategies like M&A, expansions, product launches, collaborations, and partnerships.

Significant advancements have been made in the use of viral vectors within the gene therapy & gene-modified cell therapy fields over the past 10 years. Vendors have innovated existing technologies as part of the industry's ongoing improvement efforts to support the special needs of viral vector manufacturing. These developments include the introduction of iCELLis technology for adherent cell culture and the creation of chromatographic resins for the production of viral vectors. Furthermore, next-generation analytics such as Droplet Digital Polymerase Chain Reaction (ddPCR), Analytical Ultracentrifugation (AUC), Size-Exclusion Chromatography-Multi-Angle Light Scattering (SEC-MALS), and Capillary Electrophoresis-Sodium Dodecyl Sulphate (CE-SDS) facilitate accurate & precise quantification.

List of Key Players in AAV Contract Development and Manufacturing Organizations Market

• Thermo Fischer Scientific, Inc.
• Creative Biogene
• Catalent Inc.
• Charles River Laboratories International, Inc.
• Danaher (Aldevron)
• Forge Biologics
• Genezen
• ViroCell Biologics
• Merck KGaA
• VIRALGEN
• Biovian Oy
• Esco Lifesciences (Esco Aster Pte. Ltd.)
• GenScript ProBio
• Porton Advanced Solution Ltd
• Ask Bio
• Showa Denko
• Takara Bio, Inc.
• ABL Manufacturing
• Oxford Biomedica
• Belief Biomed, Inc.
• Beijing Anlong Biomedicine Co., Ltd
• Forecyte Bio Limited
• Gene Pharma, Inc.
• Skyline Therapeutics
• TFBS Bioscience, Inc.

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AAV Contract Development And Manufacturing Organizations Market Report Highlights

• The downstream processing segment dominated the market with a revenue share of 54.8% in 2022. The main driver of this market is the small size of AAV capsids and they are very stable as compared to other viruses, so purification of AAV vectors is relatively easy
• Based on culture type, the adherent culture segment accounted for the largest revenue share of 58.9% in 2022. As they require less specialized bioengineering knowledge than three-dimensional platforms
• Based on end user, pharmaceutical and biopharmaceutical companies dominated the market with a revenue share of 53.5% in 2022and is also anticipated to show the highest growth over the forecast period
• Asia Pacific is projected to witness the fastest CAGR of 19.7% during the forecast years. The large patient base, lower overall costs, skilled workforce, and changes in the regulatory scenario are the key factors driving the market growth

AAV Contract Development And Manufacturing Organizations Market Segmentation

Grand View Research has segmented the global AAV contract development and manufacturing organizations market report based on workflow, culture type, application, end-user, and region:

Adeno-Associated Virus Contract Development And Manufacturing Organizations Workflow Outlook (Revenue, USD Million, 2018 - 2035)

• Upstream Processing
• Vector Amplification & Expansion
• Vector Recovery & Harvesting
• Downstream Processing
• Purification
• Fill Finish

Adeno-Associated Virus Contract Development And Manufacturing Organizations Culture Type Outlook (Revenue, USD Million, 2018 - 2035)

• Adherent Culture
• Suspension Culture

Adeno-Associated Virus Contract Development And Manufacturing Organizations Application Outlook (Revenue, USD Million, 2018 - 2035)

• Cell & Gene Therapy Development
• Vaccine Development
• Biopharmaceutical & Pharmaceutical Discovery
• Biomedical Research

Adeno-Associated Virus Contract Development And Manufacturing Organizations End-user Outlook (Revenue, USD Million, 2018 - 2035)

• Pharmaceutical & Biopharmaceutical Companies
• Academic & Research Institutes

Adeno-Associated Virus Contract Development And Manufacturing Organizations Regional Outlook (Revenue, USD Million, 2018 - 2035)

• North America
• U.S.
• Canada
• Europe
• U.K.
• Germany
• France
• Italy
• Spain
• Denmark
• Sweden
• Norway
• Belgium
• Switzerland
• Netherlands
• Finland
• Asia Pacific
• Japan
• China
• India
• South Korea
• Australia
• Singapore
• Malaysia
• Thailand
• Latin America
• Brazil
• Mexico
• Argentina
• Middle East & Africa
• South Africa
• Saudi Arabia
• UAE
• Kuwait

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Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, the company offers market intelligence studies ensuring relevant and fact-based research across a range of industries including technology, chemicals, materials, healthcare and energy.

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